Are there any screening tools to help diagnose neuropathic pain?

Various screening tools are available to help physicians diagnose neuropathic pain. The European Federation of Neurological Societies (EFNS) has recently published updated guidelines that provide an overview of, and recommendations on, the key screening tools. These tools are: the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS)2; Neuropathic Pain Questionnaire (NPQ)3; Douler Neuropathique en 4 questions (DN4)4; PainDETECT5; ID Pain6; and the standardized evaluation of pain (StEP)7. All these screening tools have been validated in various neuropathic pain populations; the LANSS, DN4 and StEP utilize interview questions and physical examination, while the NPQ, PainDETECT and ID Pain use only interview questions. Of relevance to the Hong Kong population, one of the screening tools – the ID Pain – has been translated to and validated. The validity of the 6-item patient-completed questionnaire was assessed in 92 patients with either neuropathic or nociceptive pain. At a score of 3 or more, the questionnaire correctly classified 71% of cases. While screening tools are useful for identifying patients with possible neuropathic pain, particularly by non-specialist physicians, they do have limitations. As noted in the EFNS guidelines, these tools fail to identify 10–20% of patients with physician-diagnosed neuropathic pain; hence, they should be used together with a thorough patient history and physical examination.

ID pain

1 Did the pain feel like pins and needles? 您的痛楚是否好像被針刺般疼痛？

2 Did the pain feel hot/burning? 您的痛楚是否灼熱或好像被火燒一樣？

3 Did the pain feel numb? 您的痛楚是否帶有麻痺？

4 Did the pain feel like electrical shocks? 您的痛楚是否好像觸電一樣？

5 Is the pain made worse with the touch of clothing or bedsheets? 您的痛楚是否因觸碰衣服或床單而加劇？

6 Is the pain limited to your joints? 您的痛楚是否只限於關節部位？

Reference: http://www.neuropainhk.org

The information provided aims to provide educational purpose, if you have the described conditions as above, please consult your doctor immediately.

Prevalence, Pathophysiology and Symptoms of Neuropathic Cancer PAIN – Hong Kong review

PAIN can be a persistent and incapacitating symptom of cancer. Although reports indicate only 15% of patients with nonmetastatic disease experience tumour-associated PAIN at the time of diagnosis, PAIN becomes more pervasive as disease progresses.1 In patients with recurrent or metastatic cancer, 67% complain of PAIN and 41% experience PAIN directly attributable to the disease. PAIN may be

chronic or acute, and patients with chronic PAIN commonly experience acute flares of PAIN. One half to two thirds of patients with well-controlled chronic PAIN experience transitory ‘breakthrough’ PAIN. Cancer-associated PAIN may be secondary to antineoplastic therapy or an unrelated comorbid condition, but is commonly due to direct tumor involvement (ie, infiltration or compression of adjacent local structures, such as bone, soft tissue, nerves or the gastrointestinal tract).1,4 Hence, cancer PAIN syndromes can be somatic, visceral or neuropathic in origin.3 Understanding and recognizing these

syndromes can help identify PAIN etiology and the need for additional evaluation, and target therapy

more appropriately.

Reference source: http://www.neuroPAINhk.org, www.brain-spine.com.hk

The above information is for educations only, if you have any related disease, please consult your neurosurgeon for more information.

Neuropathic Pain Syndromes in Hong Kong (Sciatica, cancer pain, post-stroke pain, trigeminal neuralgia, etc..)

Trigeminal neuralgia

It impacts any of the 3 trigeminal nerves that supply either side of the face, and can sometimes affect 2 branches at once. The 1-sided pain of trigeminal neuralgia may extend through the cheek, mouth, nose and/or jaw muscles. This condition is characterized by a lancinating, shooting, electric-like sensation that can last from a few seconds to several minutes. Pain may be initiated by stimulating trigger points on the face, lips or gums, or by facial muscle movement, such as chewing.

Sciatica

It is characterized by pain radiating from the back into the buttock and into the leg. The pain may travel below the knee and may also involve the foot. Lower leg muscles may become numb or weak. Sciatica is most commonly caused by prolapse of the intervertebral disc. This term is also used to describe pain anywhere along the sciatic nerve.

Cancer pain

It can be nociceptive, neuropathic or mixed in nature. Neuropathic pain in cancer patients can occur via various mechanisms, such as by nerve compression or injury caused directly by the tumour, or by cancer treatments, such as chemotherapy. Common symptoms include spontaneous burning pain, intermittent sharp or stabbing pain, hyperalgesia and allodynia.

Post-stroke pain

It is characterized by pain in body areas that have lost sensory innervation due to disruption of the spinothalamic tract as a direct result of the stroke.

Postherpetic neuralgia

It is a neuropathic pain syndrome that occurs following an acute attack of herpes zoster (shingles). It is defined as pain persisting for more than 3 months after the active herpes zoster lesions have healed, and involves constant aching, burning or itching with intermittent, severe, lancinating pain. Allodynia and hyperalgesia may also occur.

Peripheral or painful diabetic neuropathy

It is a peripheral, autonomic or cranial nerve disorder associated with diabetes mellitus. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves. It is estimated that over 50% of diabetic patients may experience a neuropathy during their lifetime, although not all neuropathies are painful. Painful neuropathy is generally described as superficial and affects the feet and hands. Burning, tingling and allodynia are typically reported.

Painful upper limb

It describes a range of painful syndromes affecting the upper limbs, such as carpal tunnel syndrome and tennis elbow. Carpal tunnel syndrome is caused by compression of the median nerve in the hand as it passes through the carpal tunnel, a narrow passage in the wrist comprised of bone and the transverse carpal ligament. Overuse, injury, friction, fractures, fluid retention and forceful movements are common causes. One of the first symptoms of carpal tunnel syndrome is numbness in the hand, thumb, index finger and middle finger, soon followed by pain in the same area.

Complex regional pain syndrome

It describes a variety of syndromes that may follow injury, commonly to an extremity. Patients describe their pain as constant, burning, aching and throbbing, and this may be combined with autonomic and tissue changes at the injury site. The pain usually begins days to weeks after the injury, and persists beyond the time normally expected for the injury to heal. The pain tends to radiate to an entire anatomic region, such as the distal leg and foot.

Reference information: www.spineuniverse.com, www.brainspine.com.hk, www.back.com.

The information above is used for educational purpose only, for any enquiries, please consult your neurosurgeon for medical advices.