1/10/2011

Prevalence, Pathophysiology and Symptoms of Neuropathic Cancer PAIN – Hong Kong review


PAIN can be a persistent and incapacitating symptom of cancer. Although reports indicate only 15% of patients with nonmetastatic disease experience tumour-associated PAIN at the time of diagnosis, PAIN becomes more pervasive as disease progresses.1 In patients with recurrent or metastatic cancer, 67% complain of PAIN and 41% experience PAIN directly attributable to the disease. PAIN may be
chronic or acute, and patients with chronic PAIN commonly experience acute flares of PAIN. One half to two thirds of patients with well-controlled chronic PAIN experience transitory ‘breakthrough’ PAIN. Cancer-associated PAIN may be secondary to antineoplastic therapy or an unrelated comorbid condition, but is commonly due to direct tumor involvement (ie, infiltration or compression of adjacent local structures, such as bone, soft tissue, nerves or the gastrointestinal tract).1,4 Hence, cancer PAIN syndromes can be somatic, visceral or neuropathic in origin.3 Understanding and recognizing these
syndromes can help identify PAIN etiology and the need for additional evaluation, and target therapy
more appropriately.

The above information is for educations only, if you have any related disease, please consult your neurosurgeon for more information.